I’ve been running the Chredge betas for a good while now, and I’m very impressed with how it works.
For one thing, it seems to be the only Chromium based browser that actually respects high-contrast windows themes. It’s not perfect, though. Sometimes it makes images disappear, but Microsoft seems to be working hard on making sure this works for people with low vision.
You can also have Chredge read articles aloud with a decent TTS voice.
I still need to dig into other options, but the changes they’ve made recently are great. I’m using Firefox as my main browser right now, but at this rate, I’m probably going to switch to Edge.